It is very important to understand that human physiology is not designed to accommodate this activity. I would not just call it unnatural but unhygienic and unhealthy too. Vagina is much different from the rectum with regard to suitability of intercourse. Vagina has lubricants and muscle network along with special kind of epithelial covering which allows friction without causing any damage. On the other hand, rectum and anus are just meant for the exit of stools. Repeated trauma, stretching and friction may cause anal sphincter to become loose leading to chronic leakage of fecal matter.
Anal intercourse can cause severe bleeding from anus. Moreover, unprotected anal intercourse leads to mixing of ejaculate and blood of the partners and highly increases the risk of transmission of HIV and other sexually transmitted diseases like syphilis and gonorrhea. for further information read- http://www.srai.org/how-healthy-is-it-to-enter-from-the-rear-gate/
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